Opportunity Information: Apply for PAR 16 348
The Small Research Grants for Analyses of Data for the Gabriella Miller Kids First Data Resource (R03) funding opportunity (PAR-16-348) is an NIH Common Fund grant designed to support small, focused research projects that make practical use of the Gabriella Miller Kids First Pediatric Research Program, often called Kids First. Kids First was created to build a high-value pediatric research data resource that combines genome sequence data with detailed phenotype and clinical information. The larger vision is to help researchers better understand the genetic and biological mechanisms that contribute to childhood cancers and structural birth defects, which in turn can improve how these conditions are diagnosed and, over time, support the development of more precise and targeted treatments. A central feature of the program is broad data sharing: the initiative aims to aggregate and standardize data across many cohorts and then make those data widely available to the research community so more investigators can ask new questions and validate findings.
This specific FOA focuses on encouraging meritorious small research projects that either analyze existing Kids First datasets or help develop datasets that are already part of the Kids First Data Resource or could reasonably be incorporated into it. In practice, that means projects might concentrate on generating new insights from available genome-wide and phenotype-linked datasets related to pediatric cancer and/or structural birth defects, improving how those datasets are curated or harmonized, or demonstrating ways the data can be used to answer well-defined scientific questions. The opportunity also explicitly welcomes projects aimed at developing or adapting statistical methods suited for genome-wide analyses in these pediatric disease areas, recognizing that childhood cancers and birth defects often present analytical challenges that differ from adult disease studies (for example, rare variant interpretation, small cohort sizes, heterogeneity across subtypes, and the need to integrate genotype with rich clinical phenotype descriptions).
The award mechanism is the NIH R03 small grant, which is intended for tightly scoped projects that can be completed with limited resources compared to larger NIH mechanisms. The listed award ceiling is $200,000. The sponsoring agency is the National Institutes of Health, and the opportunity falls under a discretionary grant category with activity areas spanning education and health-related research. The opportunity was originally posted on 2016-06-29 and lists an original closing date of 2018-01-23, indicating it was part of a specific application window in that period.
Eligibility is broad and inclusive, reflecting NIH’s intent to draw participation from many sectors capable of conducting high-quality research and data-focused work. Eligible applicants include a wide range of U.S. governmental entities (state, county, city/township governments, special districts), independent school districts, public and state-controlled institutions of higher education, and private institutions of higher education. It also includes federally recognized Native American tribal governments, tribal organizations that are not federally recognized, public housing authorities/Indian housing authorities, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), for-profit organizations other than small businesses, and small businesses. In addition, the FOA highlights categories of organizations often emphasized for broad participation, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also allows eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations), which opens the door for international collaborators where appropriate.
Overall, the grant is best understood as a targeted way to spur concrete, publishable analyses and useful dataset development activities that increase the scientific value of the Kids First Data Resource. Rather than funding large-scale data generation efforts alone, it emphasizes smaller projects that can quickly add value by analyzing shared genomic and phenotypic data, improving the readiness and usability of relevant datasets, and advancing statistical approaches that help the field extract reliable insights from genome-wide data in pediatric cancer and structural birth defects.Apply for PAR 16 348
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Small Research Grants for Analyses of Data for the Gabriella Miller Kids First Data Resource (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.273, 93.394, 93.395, 93.399, 93.853, 93.865.
- This funding opportunity was created on 2016-06-29.
- Applicants must submit their applications by 2018-01-23. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: Small Research Grants for Analyses of Data for the Gabriella Miller Kids First Data Resource (R03) (PAR-16-348)
What is this funding opportunity?
This is an NIH Common Fund grant opportunity titled "Small Research Grants for Analyses of Data for the Gabriella Miller Kids First Data Resource (R03)" (FOA: PAR-16-348). It supports small, focused research projects that make practical use of the Gabriella Miller Kids First Pediatric Research Program (Kids First) Data Resource.
Which agency is sponsoring this grant?
The sponsoring agency is the National Institutes of Health (NIH), under the NIH Common Fund.
What is the Kids First program trying to achieve?
Kids First was created to build a high-value pediatric research data resource that combines genome sequence data with detailed phenotype and clinical information. The broader goal is to help researchers understand genetic and biological mechanisms underlying childhood cancers and structural birth defects, improving diagnosis and supporting the long-term development of more precise and targeted treatments.
What makes the Kids First Data Resource distinctive?
A central feature is broad data sharing. The initiative aims to aggregate and standardize data across many cohorts and make those data widely available so more researchers can ask new questions, reproduce analyses, and validate findings using shared genomic and phenotype-linked datasets.
What types of projects does this FOA support?
The FOA encourages meritorious small research projects that (1) analyze existing Kids First datasets, or (2) help develop datasets that are already part of the Kids First Data Resource or could reasonably be incorporated into it. Projects are expected to be practical and tightly scoped, aligned with the R03 small grant mechanism.
Is the focus on new data generation or analysis of existing data?
The emphasis is on concrete analyses of shared genomic and phenotypic data and on dataset development activities that increase the scientific value and usability of the Kids First Data Resource. It is not framed as a mechanism primarily for large-scale new data generation.
What disease areas are in scope for this opportunity?
The scientific focus is on pediatric disease areas covered by Kids First, specifically childhood cancers and structural birth defects, using genome sequence data integrated with rich phenotype and clinical information.
What kinds of analyses are encouraged?
Projects may generate new insights from genome-wide and phenotype-linked datasets related to pediatric cancer and/or structural birth defects, demonstrate how Kids First data can be used to answer well-defined scientific questions, or validate findings through practical analyses of the shared data resource.
Can a project focus on improving the Kids First datasets themselves?
Yes. The FOA includes projects that improve how datasets are curated or harmonized and projects that help develop datasets already in Kids First or likely to be incorporated into the Kids First Data Resource.
Are statistical or computational method projects allowed?
Yes. The opportunity explicitly welcomes projects aimed at developing or adapting statistical methods suited for genome-wide analyses in pediatric cancer and structural birth defects.
Why does the FOA highlight method development for pediatric genome-wide studies?
It recognizes analytical challenges that often differ from adult disease studies, including rare variant interpretation, small cohort sizes, heterogeneity across subtypes, and the need to integrate genotype with rich clinical phenotype descriptions.
What is the award mechanism?
The award mechanism is the NIH R03 small grant, intended for tightly scoped projects that can be completed with limited resources compared to larger NIH mechanisms.
What is the funding ceiling for this opportunity?
The listed award ceiling is $200,000.
When was this opportunity posted and when did it close?
The opportunity was originally posted on 2016-06-29 and lists an original closing date of 2018-01-23, indicating it was tied to a specific application window during that period.
What grant category or activity areas does it fall under?
It is described as a discretionary grant category with activity areas spanning education and health-related research.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include U.S. governmental entities (state, county, city/township governments, special districts), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, tribal governments (federally recognized), and tribal organizations (including those not federally recognized).
Are nonprofits eligible?
Yes. Nonprofit organizations are eligible, including both 501(c)(3) and non-501(c)(3) organizations.
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are listed as eligible, and small businesses are also explicitly listed as eligible.
Are minority-serving institutions specifically included?
Yes. The FOA highlights categories often emphasized for broad participation, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included among eligible applicants.
Are non-U.S. (foreign) organizations eligible?
Yes. The eligibility list includes non-U.S. entities (foreign organizations), which can allow international participation where appropriate.
Are federal agencies allowed to apply?
Yes. Eligible federal agencies are included among eligible applicants.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are listed as eligible applicants.
Are housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are included in the eligibility list.
What is the practical aim of funding these smaller R03 projects?
The aim is to spur concrete, publishable analyses and useful dataset development activities that increase the scientific value of the Kids First Data Resource. The intent is to quickly add value by analyzing shared data, improving dataset readiness and usability, and advancing statistical approaches for genome-wide pediatric research.
What does "broad data sharing" mean in the context of Kids First?
Based on the description provided, it refers to aggregating and standardizing data across cohorts and making those data widely available to the research community so that more investigators can ask new questions and validate findings using shared resources.
What kinds of datasets are central to Kids First and therefore relevant here?
The Kids First resource is described as combining genome sequence data with detailed phenotype and clinical information, particularly for pediatric cancer and structural birth defects. Projects supported by this FOA are expected to make practical use of those types of datasets.
Does this FOA support work that demonstrates how to use Kids First data?
Yes. The FOA describes projects that demonstrate ways the data can be used to answer well-defined scientific questions, alongside projects that generate new insights, improve curation/harmonization, or develop/adapt statistical methods.
Is this opportunity intended for large, multi-year projects?
The mechanism is an NIH R03 small grant, and the FOA is framed around small, tightly scoped projects that can be completed with limited resources compared to larger NIH mechanisms.
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