Opportunity Information: Apply for PAR 16 366
The Dual Purpose with Dual Benefit: Research in Biomedicine and Agriculture Using Agriculturally Important Domestic Animal Species (R01) funding opportunity (PAR-16-366) is an interagency research grant announcement led by the National Institutes of Health that supports projects using farm and other agriculturally important domestic animal species as research models to advance both human health and animal agriculture. The central idea is "comparative medicine": choosing and improving animal models that closely mirror key human developmental, physiological, and disease-causing processes, then using those models to generate insights that matter to biomedical science while also producing practical benefits for food-animal production, animal health, and product quality. The FOA is positioned to fund both basic and translational research, meaning it can support fundamental biological discovery as well as work aimed at improving prevention, diagnosis, and treatment strategies that may move toward real-world applications.
Scientifically, the FOA encourages studies where the farm animal model is not incidental, but intentionally selected and refined because it can mimic aspects of human biology better than traditional laboratory species for specific questions. The announcement highlights several priority areas where these models can be especially informative: understanding fertility and infertility, clarifying normal and abnormal metabolism, examining how early-life and developmental conditions contribute to later disease risk (the developmental origins of disease), and strengthening prevention and treatment of infectious diseases that affect both humans and agriculturally important animals. In practice, this could include work that leverages similarities in organ development, endocrine function, immune responses, or disease progression between humans and species such as swine, cattle, sheep, goats, or poultry, depending on the scientific question and the comparative rationale.
A defining requirement in the spirit of this opportunity is dual relevance. The expected impact is twofold: first, generating fundamental knowledge and translational insights that improve human health; and second, delivering outcomes that can improve agricultural productivity, animal well-being, and the quality of animal-derived products. The FOA makes clear that applications are envisioned to fit mission-relevant priorities of both participating agencies, so proposals are expected to articulate benefits on both the biomedical side and the agricultural side, rather than focusing exclusively on one domain. The goal is not simply to use agricultural animals in a biomedical study, but to design research where the model choice strengthens the science and where the findings can realistically inform both medicine and animal agriculture.
From an administrative standpoint, this is a discretionary grant program using the NIH R01 mechanism, which typically supports investigator-initiated research projects of substantial scope. The funding activity category is listed under Health, Income Security and Social Services, and the CFDA number associated with the opportunity is 93.865. The opportunity record indicates it was created on 2016-07-12, with an original closing date of 2018-09-27. While an award ceiling and expected awards count are not specified in the provided listing, applicants would normally consult the full FOA and NIH grants policy guidance for budget expectations, allowable costs, and submission requirements.
Eligibility is broad and includes many organization types that commonly participate in federally funded research. Eligible applicants listed include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofit organizations (both 501(c)(3) and non-501(c)(3)) other than institutions of higher education; for-profit organizations other than small businesses; small businesses; and additional applicants categorized as "others." The FOA also explicitly notes additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, Indian/Native American tribal governments other than federally recognized entities, and non-domestic (non-U.S.) entities/foreign organizations. This breadth signals an intent to draw from a wide research community, including institutions serving underrepresented populations and international partners where relevant and allowable.
Overall, this opportunity is best understood as a bridge between biomedical research and animal agriculture, using thoughtfully selected domestic animal models to answer questions that are difficult to tackle in other systems. Competitive applications under this FOA would be expected to make a clear case for why the chosen agriculturally important species is the right model, how the approach advances mechanistic understanding or translational progress for human health, and how the same work yields tangible or informative benefits for animal health, production efficiency, or product quality.Apply for PAR 16 366
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Dual Purpose with Dual Benefit: Research in Biomedicine and Agriculture Using Agriculturally Important Domestic Animal Species (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865.
- This funding opportunity was created on 2016-07-12.
- Applicants must submit their applications by 2018-09-27. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the "Dual Purpose with Dual Benefit" (PAR-16-366) R01 opportunity?
PAR-16-366 is an interagency research grant announcement led by the National Institutes of Health (NIH) that funds R01 research projects using farm and other agriculturally important domestic animal species as research models. The goal is to generate results that advance both human health (biomedicine) and animal agriculture.
What is the main scientific concept behind this funding opportunity?
The central idea is comparative medicine: selecting and improving agriculturally important domestic animal models that mirror key human developmental, physiological, and disease processes. These models are then used to produce insights relevant to biomedical science while also supporting practical improvements in food-animal production, animal health, and product quality.
Is this opportunity focused on basic research, translational research, or both?
It is positioned to support both basic and translational research. That includes fundamental biological discovery as well as research aimed at improving prevention, diagnosis, and treatment strategies that may move toward real-world applications.
What does "dual purpose" and "dual benefit" mean for applicants?
Applications are expected to demonstrate two forms of impact: (1) advancing knowledge and/or translational insights that improve human health, and (2) producing outcomes that can improve agricultural productivity, animal well-being, and/or the quality of animal-derived products. Proposals are expected to articulate benefits on both the biomedical side and the agricultural side, not just one.
Do projects have to use farm animals in a specific way to be competitive?
Yes. The FOA emphasizes that the farm animal model should not be incidental. The domestic animal species should be intentionally selected and refined because it can mimic aspects of human biology better than traditional laboratory species for the specific research question.
Which domestic animal species are relevant under this FOA?
The opportunity focuses on farm and other agriculturally important domestic animal species. Examples mentioned include swine, cattle, sheep, goats, and poultry, with the specific species choice driven by the scientific question and the comparative rationale.
What kinds of biological similarities might justify using an agriculturally important domestic animal model?
The FOA points to leveraging similarities between humans and domestic animal species in areas such as organ development, endocrine function, immune responses, and disease progression, depending on the research question.
What priority research areas does the FOA highlight?
The announcement highlights areas where agriculturally important domestic animal models can be especially informative, including fertility and infertility, normal and abnormal metabolism, developmental origins of disease (how early-life conditions influence later disease risk), and prevention and treatment of infectious diseases affecting both humans and agriculturally important animals.
Does the FOA support research on infectious diseases?
Yes. Strengthening prevention and treatment of infectious diseases that affect both humans and agriculturally important animals is specifically listed as a priority area.
Does the FOA support research related to development and early-life effects on later disease?
Yes. The FOA highlights developmental origins of disease, including how early-life and developmental conditions contribute to later disease risk.
Does this opportunity require that results directly improve agriculture outcomes?
The stated expectation is dual relevance, including agricultural-side benefits such as improved animal health, production efficiency, animal well-being, or product quality. Applications are envisioned to articulate realistic benefits for both medicine and animal agriculture rather than focusing exclusively on one domain.
What grant mechanism is used for this opportunity?
This is a discretionary grant program using the NIH R01 mechanism, which typically supports investigator-initiated research projects of substantial scope.
Who is leading this grant announcement?
The announcement is described as an interagency research grant announcement led by the National Institutes of Health (NIH).
What is the CFDA number associated with this opportunity?
The CFDA number listed for this opportunity is 93.865.
What funding activity category is listed for the opportunity?
The funding activity category is listed as Health, Income Security and Social Services.
When was the opportunity record created, and what was the original closing date?
The opportunity record indicates it was created on 2016-07-12, with an original closing date of 2018-09-27.
Are the award ceiling and expected number of awards specified in the listing provided?
No. The provided listing does not specify an award ceiling or the expected number of awards.
Where should applicants look for budget expectations, allowable costs, and submission requirements?
The listing notes that applicants would normally consult the full FOA and NIH grants policy guidance for budget expectations, allowable costs, and submission requirements.
Which types of organizations are eligible to apply?
Eligibility is broad and includes state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofit organizations (501(c)(3) and non-501(c)(3)) other than institutions of higher education; for-profit organizations other than small businesses; small businesses; and other applicants categorized as "others."
Are institutions serving underrepresented populations explicitly included as eligible applicants?
Yes. The FOA explicitly notes eligible applicant categories including Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly listed among additional eligible applicant categories.
Can federal agencies apply?
Yes. Eligible federal agencies are explicitly listed among additional eligible applicant categories.
Are U.S. territories or possessions included in eligibility?
Yes. U.S. territories or possessions are explicitly listed among additional eligible applicant categories.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. Non-domestic (non-U.S.) entities/foreign organizations are explicitly listed as eligible applicant categories.
What would a competitive application generally need to demonstrate under this FOA?
Based on the description provided, a competitive application would be expected to: (1) clearly justify why the chosen agriculturally important species is the right model for the question, (2) explain how the work advances mechanistic understanding and/or translational progress for human health, and (3) show how the same work yields tangible or informative benefits for animal health, production efficiency, animal well-being, and/or product quality.
Is the goal simply to use agricultural animals in biomedical studies?
No. The stated goal is not simply to use agricultural animals in a biomedical study, but to design research where the model choice strengthens the science and where the findings can realistically inform both medicine and animal agriculture.
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