Opportunity Information: Apply for HT942526AZRPTRRA
The FY26 Alzheimer s Research Program (AZRP) Transforming Research Award (TrRA) is a Department of the Army (USAMRAA) discretionary grant opportunity designed to fund bold, non-incremental research that can materially shift how the field reduces risk for, and ultimately prevents, Alzheimer s disease and Alzheimer s disease related dementias (AD/ADRD). The program is looking for robust, well-designed projects with a clear path to transformative impact, meaning proposals should not be framed as small extensions of prior work. Instead, they should aim to produce meaningful advances that could accelerate practical solutions for prevention or risk reduction.
Applications must align with at least one of two stated focus areas. The first, Risk Factor Knowledge, supports research that improves the understanding, identification, and/or validation of risk factors or protective factors for AD/ADRD, with an emphasis on outcomes or products that help speed real-world solutions. The opportunity explicitly welcomes a broad range of risk domains, including environmental, epigenetic, genetic, lifestyle, occupational, and other underexplored or emerging risk categories. The second focus area, Risk Reduction Solutions, supports research aimed at developing or refining methods, technologies, or strategies that contribute to lowering risk and preventing AD/ADRD. In both cases, the expectation is that the work will move beyond description and toward actionable insight, tools, or approaches that can change prevention trajectories.
The award permits clinical research, but it draws two firm boundaries: clinical trials are not allowed, and animal research is prohibited. This means the program is open to human-centered studies that may involve observational designs, mechanistic investigations in humans, analyses of human datasets or biospecimens, or development and validation work that does not cross into an interventional clinical trial framework. Applicants must include preliminary data, signaling that the research should be grounded in evidence of feasibility and a credible rationale rather than being purely exploratory.
For studies that will prospectively enroll human subjects, community collaboration is a required component. In practice, this implies applicants should plan for meaningful partnership with the relevant community or communities, such as engagement in study design, recruitment strategies, retention planning, culturally informed procedures, and communication of results. The intent is to strengthen feasibility, relevance, and trust, and to ensure that the research is responsive to real community needs and contexts rather than being conducted in isolation from the populations it aims to serve.
The TrRA also includes a Career Initiation or Transition (CIT) Partnership Option that supports multi-PI collaborations, including both new and established partnerships. Under this option, if the project is selected for funding, each principal investigator is named on a separate award made to their respective organization(s), which can help structure cross-institutional collaborations. The notice indicates that if this option is used, at least one independent investigator must meet the eligibility requirement tied to the CIT structure (the provided text is truncated, but the clear takeaway is that the partnership option is designed to support team science while ensuring appropriate investigator status within the collaboration).
Administratively, the opportunity is listed as Funding Opportunity Number HT942526AZRPTRRA under CFDA 12.420, categorized under Science and Technology and other Research and Development. Eligibility is described as unrestricted. The application deadline is September 24, 2026. The anticipated number of awards is four, and the award ceiling is not stated in the provided listing, suggesting applicants should consult the full announcement for budget limits and any cost constraints. Overall, this funding opportunity is positioned for teams with strong preliminary evidence and a prevention-oriented research plan that can credibly deliver high-impact advances in AD/ADRD risk factor understanding or risk reduction approaches, while staying within the non-trial, non-animal research boundaries.Apply for HT942526AZRPTRRA
- The Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoW Alzheimer’s Transforming Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on 2026-05-01.
- Applicants must submit their applications by 2026-09-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Unrestricted.
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FY26 Alzheimer's Research Program (AZRP) Transforming Research Award (TrRA) FAQs
What is the FY26 AZRP Transforming Research Award (TrRA)?
The FY26 Alzheimer's Research Program (AZRP) Transforming Research Award (TrRA) is a discretionary grant opportunity from the Department of the Army (USAMRAA). It is intended to support bold, non-incremental research that can materially shift how the field reduces risk for, and ultimately prevents, Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD).
What kinds of projects is this award trying to fund?
The program is looking for robust, well-designed projects with a clear path to transformative impact. Proposals are expected to go beyond small extensions of prior work and instead aim for meaningful advances that could accelerate practical solutions for prevention or risk reduction of AD/ADRD.
What are the required focus areas for an application?
Applications must align with at least one of two focus areas: (1) Risk Factor Knowledge, or (2) Risk Reduction Solutions.
What does the "Risk Factor Knowledge" focus area include?
Risk Factor Knowledge supports research that improves the understanding, identification, and/or validation of risk factors or protective factors for AD/ADRD, with an emphasis on outcomes or products that help speed real-world solutions.
What risk domains are explicitly welcomed under "Risk Factor Knowledge"?
The opportunity welcomes a broad range of risk domains, including environmental, epigenetic, genetic, lifestyle, occupational, and other underexplored or emerging risk categories.
What does the "Risk Reduction Solutions" focus area include?
Risk Reduction Solutions supports research aimed at developing or refining methods, technologies, or strategies that contribute to lowering risk and preventing AD/ADRD. The expectation is that projects move beyond description toward actionable tools, approaches, or insights that can change prevention trajectories.
Is clinical research allowed under this award?
Yes. The award permits clinical research, as long as it stays within the stated boundaries (including no clinical trials and no animal research).
Are clinical trials allowed?
No. Clinical trials are not allowed under this funding opportunity.
Is animal research allowed?
No. Animal research is prohibited under this funding opportunity.
What types of human-centered research approaches seem to fit this program?
Based on the description, the program is open to human-centered studies such as observational designs, mechanistic investigations in humans, analyses of human datasets or biospecimens, and development and validation work, as long as the work does not cross into an interventional clinical trial framework.
Is preliminary data required?
Yes. Applicants must include preliminary data, indicating that proposed work should be supported by feasibility evidence and a credible rationale rather than being purely exploratory.
When is community collaboration required?
Community collaboration is required for studies that will prospectively enroll human subjects.
What does "community collaboration" mean in practice for prospective human enrollment studies?
The description indicates applicants should plan for meaningful partnerships with relevant communities. Examples include community engagement in study design, recruitment strategies, retention planning, culturally informed procedures, and communication of results. The intent is to strengthen feasibility, relevance, trust, and responsiveness to community needs and contexts.
Does this award have an option to support multi-PI partnerships?
Yes. The TrRA includes a Career Initiation or Transition (CIT) Partnership Option that supports multi-PI collaborations, including new and established partnerships.
How do awards work under the CIT Partnership Option if selected for funding?
Under the CIT Partnership Option, if the project is selected for funding, each principal investigator is named on a separate award made to their respective organization(s). This structure can support cross-institutional collaborations.
Are there specific eligibility conditions tied to the CIT Partnership Option?
The notice indicates that if the CIT Partnership Option is used, at least one independent investigator must meet an eligibility requirement tied to the CIT structure. The provided text is truncated, so applicants would need to consult the full announcement for the exact requirement.
Who is eligible to apply?
Eligibility is described as unrestricted in the provided listing.
What is the Funding Opportunity Number for this grant?
The Funding Opportunity Number is HT942526AZRPTRRA.
What CFDA number is associated with this opportunity?
This opportunity is listed under CFDA 12.420.
How is this funding opportunity categorized?
It is categorized under Science and Technology and other Research and Development.
What is the application deadline?
The application deadline is September 24, 2026.
How many awards are anticipated?
The anticipated number of awards is four.
What is the maximum award amount (award ceiling)?
The award ceiling is not stated in the provided listing. Applicants are expected to consult the full announcement for budget limits and any cost constraints.
What is the main theme or goal across both focus areas?
Across both focus areas, the program emphasizes prevention-oriented research that can credibly deliver high-impact advances in AD/ADRD risk factor understanding or risk reduction approaches, while remaining non-incremental and staying within the non-trial, non-animal research boundaries.
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