Opportunity Information: Apply for RFA DK 26 308
The Limited Competition Renewal for the Continuation of the Liver Cirrhosis Network: Clinical Research Centers (U01 Clinical Trial Required) is an NIH Notice of Funding Opportunity (NOFO) designed to support the continued operation of Liver Cirrhosis Network Clinical Research Centers through a cooperative agreement mechanism (U01). Because it is a limited competition, it is not open to the broader research community; only organizations that are currently funded under the prior Liver Cirrhosis Network award mechanism tied to RFA-DK-20-003 are intended to be eligible to apply. Applications submitted under this renewal will still go through NIH standard peer-review, meaning proposals will be evaluated competitively for scientific and operational merit, and only those judged meritorious will be considered for funding.
This opportunity is categorized as discretionary federal assistance and falls under the health activity area, with CFDA number 93.847. The funding instrument is a cooperative agreement, which typically indicates substantial NIH program involvement compared with a standard research project grant. The title also specifies "Clinical Trial Required," signaling that the supported centers are expected to conduct clinical trials or clinical trial-related research activities as part of their core mission within the network, rather than only observational or purely mechanistic studies.
Eligibility is broad in the abstract sense (for example, various levels of government, public and private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, for-profit organizations other than small businesses, and small businesses are listed). However, the practical eligibility constraint is decisive: the NOFO is specifically intended to fund only those organizations that are existing grant recipients from the earlier competition (RFA-DK-20-003). In other words, even if an entity type is generally eligible under NIH rules, it would not be competitive or potentially not allowable if it is not part of the defined limited-competition pool. The NOFO instructs applicants to consult Section III (Eligibility Information) for the definitive eligibility requirements.
The NOFO makes strict restrictions on foreign participation. Non-U.S. (foreign) organizations are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by the NIH Grants Policy Statement) are not permitted. Practically, that means the work supported under this renewal must be carried out without foreign components as part of the funded project structure, even if investigators have informal international collaborations outside the scope of the award.
Key administrative details include the funding opportunity number RFA DK 26 308 and an original application closing date of March 8, 2027. The award ceiling is listed as $330,214, and NIH expects to make approximately 10 awards. The opportunity was created on December 5, 2025. Taken together, the announcement is essentially a continuation funding pathway for existing Liver Cirrhosis Network Clinical Research Centers, keeping the network infrastructure and clinical trial capabilities in place under NIH oversight through the U01 cooperative agreement model, while limiting eligibility to the currently participating, previously funded awardees.Apply for RFA DK 26 308
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition Renewal for the Continuation of the Liver Cirrhosis Network: Clinical Research Centers (U01 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2025-12-05.
- Applicants must submit their applications by 2027-03-08.
- Each selected applicant is eligible to receive up to $330,214.00 in funding.
- The number of recipients for this funding is limited to 10 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
1. What is this funding opportunity?
This is an NIH Notice of Funding Opportunity (NOFO) titled: "Limited Competition Renewal for the Continuation of the Liver Cirrhosis Network: Clinical Research Centers (U01 Clinical Trial Required)." It supports the continued operation of Liver Cirrhosis Network Clinical Research Centers through a U01 cooperative agreement.
2. What is the purpose of this NOFO?
The purpose is to continue funding existing Liver Cirrhosis Network Clinical Research Centers so the network infrastructure and clinical trial capabilities remain in place under NIH oversight, rather than starting a brand-new, open competition.
3. Is this a limited competition?
Yes. This is explicitly a limited competition renewal and is not open to the broader research community.
4. Who is eligible to apply?
In practical terms, eligibility is intended for organizations that are currently funded under the prior Liver Cirrhosis Network award mechanism tied to RFA-DK-20-003. Even though many organization types may be listed as generally eligible under NIH policies, the decisive constraint is that this NOFO is meant for existing awardees from the earlier competition.
5. What prior award is this renewal tied to?
This renewal is tied to the earlier competition identified as RFA-DK-20-003.
6. If my organization type is listed as eligible under NIH rules, can I apply even if we are not currently funded under RFA-DK-20-003?
The NOFO is described as a limited competition intended to fund only organizations that are existing grant recipients from the earlier Liver Cirrhosis Network competition (RFA-DK-20-003). Based on the information provided, organizations outside that limited pool are not intended to be eligible.
7. Where are the definitive eligibility rules located?
The NOFO instructs applicants to consult Section III (Eligibility Information) for the definitive eligibility requirements.
8. Are foreign organizations eligible to apply?
No. Non-U.S. (foreign) organizations are not eligible to apply under this NOFO.
9. Can a U.S. organization include a non-U.S. component on this award?
No. Non-U.S. components of U.S. organizations are not eligible under this opportunity.
10. Are foreign components allowed in any form?
No. Foreign components (as defined by the NIH Grants Policy Statement) are not permitted.
11. What does "Clinical Trial Required" mean for applicants?
The title specifies "Clinical Trial Required," which signals that supported centers are expected to conduct clinical trials or clinical trial-related research activities as part of their core mission within the network, not only observational studies or purely mechanistic research.
12. What type of funding mechanism is used?
The funding instrument is a cooperative agreement using the U01 activity code.
13. What does a U01 cooperative agreement imply compared with a standard NIH research grant?
A cooperative agreement typically indicates substantial NIH program involvement compared with a standard research project grant. This means NIH is expected to have a more active role in the project during the award period.
14. Will applications be peer-reviewed?
Yes. Applications will go through NIH standard peer review and will be evaluated competitively for scientific and operational merit. Only applications judged meritorious will be considered for funding.
15. Is funding guaranteed for existing centers?
No. Even though this is a renewal limited to current awardees, applications still undergo competitive peer review and must be judged meritorious to be considered for funding.
16. What is the funding opportunity number?
The funding opportunity number is RFA DK 26 308.
17. What is the CFDA number and activity area for this opportunity?
The opportunity falls under the health activity area and lists CFDA number 93.847.
18. What kind of federal assistance is this categorized as?
This opportunity is categorized as discretionary federal assistance.
19. What is the application closing date?
The original application closing date is March 8, 2027.
20. What is the award ceiling?
The award ceiling is listed as $330,214.
21. How many awards does NIH expect to make?
NIH expects to make approximately 10 awards.
22. When was this opportunity created?
The opportunity was created on December 5, 2025.
23. What is being supported through this renewal?
Based on the description provided, the renewal supports continuation of the Liver Cirrhosis Network Clinical Research Centers, including the network infrastructure and clinical trial (or clinical trial-related) capabilities, under NIH involvement consistent with the U01 cooperative agreement model.
24. Can applicants rely on informal international collaborations?
The NOFO states foreign components are not permitted. The description notes that investigators may have informal international collaborations outside the scope of the award, but the funded project structure itself must not include foreign components.
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