Opportunity Information: Apply for PAR 23 155
The National Institutes of Health funding opportunity "Understanding Expectancies in Cancer Symptom Management (R01 Clinical Trial Required)" (PAR-23-155; CFDA 93.393) supports research focused on how expectancies are formed and how they influence cancer symptom management and related outcomes. In this program, "expectancies" means beliefs about future outcomes, including what a person thinks will happen in response to cancer itself or to cancer treatment. The NOFO is centered on the idea that these expectations can shape real-world symptom experiences and health outcomes, and it seeks studies that can clearly explain the mechanisms behind those effects rather than only describing that they exist.
A key emphasis is mechanistic research that clarifies how and why expectancy effects occur in cancer settings. Applicants are expected to investigate expectancy-generating factors and to measure their effects on expectancies and downstream outcomes in symptom management. The opportunity also calls for research that identifies moderators, meaning it wants investigators to determine for whom and under what circumstances expectancy effects are stronger or weaker. This includes identifying the patients, symptom types, cancer sites, and care contexts where expectancy effects can be reliably leveraged to improve outcomes. In practical terms, the program is looking for work that can move beyond general placebo/nocebo discussions and instead map specific pathways that connect social or informational cues to beliefs, and then to cognitive, behavioral, and biological responses that matter for symptom burden and quality of life.
The NOFO recognizes that expectancies can be evoked by many sources and settings, including social, psychological, environmental, and systemic factors. It also expands the lens beyond the patient alone: expectancy effects may be generated by beliefs held by clinicians, family members, caregivers, and dyads or broader social networks. That framing encourages studies that examine clinical communication, caregiving dynamics, cultural and community influences, and health system features that shape what people anticipate about symptoms and treatment effects. "Expectancy effects" are explicitly defined as the cognitive, behavioral, and biological outcomes caused by these expectancies, signaling interest in multi-level outcomes that could include symptom ratings and functional outcomes alongside behavioral adherence patterns and measurable biological correlates, depending on the study design.
This is an R01 grant mechanism and the title specifies "Clinical Trial Required," indicating that the supported projects must include a clinical trial component consistent with NIH definitions. While the NOFO summary provided does not list an award ceiling or expected number of awards, it is categorized as a discretionary grant opportunity under the education and health activity category, administered by NIH. The original closing date listed is 2023-08-11, and the opportunity was created on 2023-04-12.
Eligibility is broad and includes many organization types such as state, county, and local governments; public and private institutions of higher education; independent school districts; special district governments; Native American tribal governments (federally recognized) and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status; for-profit organizations (other than small businesses) and small businesses; and other entities. The NOFO also explicitly highlights additional eligible applicant categories including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations). Alongside these eligibility details, the program expresses a particular interest in applications that enroll individuals and groups from populations historically underrepresented or excluded from biomedical and behavioral research, signaling that representativeness and inclusion are program priorities rather than secondary considerations.
Overall, this opportunity funds clinical trial-based, mechanism-oriented research aimed at understanding and harnessing expectancy effects to improve cancer symptom management. The work NIH is encouraging sits at the intersection of psychology, communication, behavioral medicine, and oncology supportive care, with a strong emphasis on identifying actionable contexts and moderators so expectancy effects can be responsibly and effectively applied to reduce symptom burden and improve cancer-related outcomes across diverse populations.Apply for PAR 23 155
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Understanding Expectancies in Cancer Symptom Management (R01 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393.
- This funding opportunity was created on 2023-04-12.
- Applicants must submit their applications by 2023-08-11. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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