Opportunity Information: Apply for RFA CA 17 030
The HIV/AIDS and the Tumor Niche (R01) funding opportunity (RFA-CA-17-030) is a National Institutes of Health (NIH) discretionary grant that supports research aimed at clarifying how the tumor niche, also called the tumor microenvironment, shapes cancer risk and outcomes in people living with HIV or with AIDS. The central scientific focus is not only on tumor cells themselves, but on the surrounding biological context that can influence whether cancers arise, how quickly they progress, how they are detected, and how they respond to treatment. In practical terms, the FOA is interested in studies that explain why certain cancers may behave differently in the setting of chronic HIV infection, immune dysregulation, inflammation, co-infections, or effects of long-term therapy, and how those factors interact with the local cellular and molecular environment within tumors.
This FOA explicitly frames the tumor microenvironment as a key driver across the full cancer continuum for HIV-affected populations: cancer risks (why cancer develops in the first place), development and progression (how tumors evolve and spread), diagnosis (how microenvironmental features might affect biomarkers or detectability), and treatment (how the niche influences therapeutic response and resistance). By funding R01 projects, NIH is signaling interest in substantial, hypothesis-driven work that can produce mechanistic insight and potentially identify actionable targets, whether those targets are immune cells, stromal components, cytokine networks, vascular factors, extracellular matrix dynamics, microbial or viral co-factors, or other microenvironmental features that are altered by HIV infection.
From an applicant standpoint, eligibility is broad and includes many types of U.S. organizations and governmental entities, as well as certain non-U.S. participants. Eligible applicants include state, county, city or township governments, special district governments, and independent school districts, along with public and state-controlled institutions of higher education and private institutions of higher education. Tribal eligibility includes federally recognized Native American tribal governments, tribal organizations other than federally recognized tribal governments, and Indian/Native American tribal governments that are not federally recognized. The FOA also allows participation from public housing authorities/Indian housing authorities. Nonprofit organizations are eligible whether they have 501(c)(3) status or not, as long as they are not institutions of higher education, and for-profit organizations (other than small businesses) and small businesses are also eligible. Beyond these standard categories, the announcement highlights additional eligible applicant groups such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs). It also notes that faith-based or community-based organizations may apply, as can eligible federal agencies, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations), underscoring an interest in reaching diverse research settings and populations.
Administratively, the opportunity is listed under Assistance Listing/CFDA number 93.396 and falls within the education and health activity category. The FOA was created on 2017-05-26, and the original closing date was 2018-08-07. The funding instrument type is a grant, using the NIH R01 mechanism, which typically supports multi-year, investigator-initiated research programs at a scale suitable for in-depth mechanistic studies, development of models, and comprehensive analyses of biological pathways. The listing does not specify an award ceiling or expected number of awards in the provided source data, so those details would normally be confirmed in the full FOA text or NIH award information.
Overall, the opportunity is best understood as an NIH effort to close important knowledge gaps at the intersection of HIV/AIDS and cancer biology by pushing the field to look closely at the tumor microenvironment. The intended payoff is a clearer understanding of how HIV-related immune and inflammatory changes reshape the niche in ways that affect cancer initiation, progression, and treatment response, with the longer-term goal of improving diagnostic approaches and therapeutic strategies for people living with HIV who develop cancer.Apply for RFA CA 17 030
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "HIV/AIDS and the Tumor Niche (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.396.
- This funding opportunity was created on 2017-05-26.
- Applicants must submit their applications by 2018-08-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled HIV/AIDS and the Tumor Niche (R01) and is identified as RFA-CA-17-030.
What type of grant mechanism does this opportunity use?
This funding opportunity uses the NIH R01 mechanism and the funding instrument type is a grant.
Which agency is offering this grant?
This is a National Institutes of Health (NIH) discretionary grant opportunity.
What is the main research goal of this FOA?
The goal is to support research that clarifies how the tumor niche (also called the tumor microenvironment) shapes cancer risk and outcomes in people living with HIV or with AIDS.
What does the FOA mean by the "tumor niche" or "tumor microenvironment"?
In this FOA, the tumor niche/microenvironment refers to the surrounding biological context around tumor cells that can influence whether cancers arise, how quickly they progress, how they are detected, and how they respond to treatment.
Is the scientific focus only on tumor cells?
No. The FOA explicitly emphasizes that the central scientific focus is not only on tumor cells but also on the surrounding cellular and molecular environment that can shape cancer behavior in HIV-affected populations.
What kinds of HIV-related factors does the FOA want researchers to consider?
The FOA is interested in studies that explain how cancers may behave differently in the setting of chronic HIV infection, immune dysregulation, inflammation, co-infections, and/or the effects of long-term therapy, and how these factors interact with the local tumor microenvironment.
Which parts of the cancer "continuum" are included in the FOA's scope?
The FOA frames the tumor microenvironment as a driver across the full cancer continuum for HIV-affected populations, including: cancer risk (why cancer develops), development and progression (how tumors evolve and spread), diagnosis (how microenvironmental features might affect biomarkers or detectability), and treatment (how the niche influences therapeutic response and resistance).
What kinds of research outputs or impacts is NIH signaling interest in?
By funding R01 projects, NIH is signaling interest in substantial, hypothesis-driven research that can produce mechanistic insight and potentially identify actionable targets relevant to cancer in people living with HIV.
What are examples of "actionable targets" or microenvironment features mentioned in the FOA?
The FOA gives examples of potential targets or features such as immune cells, stromal components, cytokine networks, vascular factors, extracellular matrix dynamics, and microbial or viral co-factors, as well as other microenvironmental features altered by HIV infection.
Who is eligible to apply (in general terms)?
Eligibility is described as broad and includes many types of U.S. organizations and governmental entities, as well as certain non-U.S. participants (foreign organizations are explicitly noted as eligible).
Which government entities are listed as eligible applicants?
Eligible government applicants include state, county, city or township governments, special district governments, and independent school districts.
Are institutions of higher education eligible?
Yes. The FOA includes public and state-controlled institutions of higher education and private institutions of higher education as eligible applicants.
Are tribal governments and tribal organizations eligible?
Yes. Eligibility includes federally recognized Native American tribal governments, tribal organizations other than federally recognized tribal governments, and Indian/Native American tribal governments that are not federally recognized.
Are public housing authorities eligible?
Yes. The FOA allows participation from public housing authorities/Indian housing authorities.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations are eligible whether they have 501(c)(3) status or not, as long as they are not institutions of higher education.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) and small businesses are listed as eligible applicants.
Does the FOA highlight eligibility for specific minority-serving institutions?
Yes. It specifically highlights eligibility for Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Can faith-based or community-based organizations apply?
Yes. The FOA notes that faith-based or community-based organizations may apply.
Are federal agencies eligible to apply?
Yes. The FOA states that eligible federal agencies may apply.
Are U.S. territories or possessions included in eligibility?
Yes. The FOA includes U.S. territories or possessions among eligible applicant groups.
Are non-U.S. (foreign) organizations allowed to apply?
Yes. The FOA explicitly notes that non-domestic (non-U.S.) entities (foreign organizations) are eligible.
What is the Assistance Listing (CFDA) number for this opportunity?
The Assistance Listing/CFDA number provided is 93.396.
What activity category is associated with this listing?
The listing is categorized under education and health.
When was the FOA created?
The FOA was created on 2017-05-26.
What was the original closing date listed for the FOA?
The original closing date was 2018-08-07.
Does the provided information specify an award ceiling or the expected number of awards?
No. The provided source information does not specify an award ceiling or the expected number of awards. Those details would typically be confirmed in the full FOA text or NIH award information.
What is the overall purpose or intended payoff of this program?
The program aims to close knowledge gaps at the intersection of HIV/AIDS and cancer biology by focusing on the tumor microenvironment, with a longer-term goal of improving diagnostic approaches and therapeutic strategies for people living with HIV who develop cancer.
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