Opportunity Information: Apply for RFA CA 23 014

The National Institutes of Health, through the National Cancer Institute (NCI) Informatics Technology for Cancer Research (ITCR) Program, released this Funding Opportunity Announcement (RFA-CA-23-014) to support exploratory and developmental projects that create genuinely new informatics methods and algorithms for cancer research and cancer care-related research. It uses the R21 grant mechanism (clinical trial optional) and is meant for early-stage, high-risk, high-reward work that can open up new technical directions rather than incrementally extending existing tools.

The central goal is to fund innovative computational approaches that improve how cancer-related data are acquired, analyzed, visualized, or interpreted across the full cancer research continuum. That scope is intentionally broad and can include, for example, cancer biology and mechanisms, diagnosis and treatment, early detection, risk assessment and prevention, cancer control and epidemiology, and research addressing cancer health disparities. In practical terms, applicants are expected to propose new informatics capabilities that could speed up discovery, make analyses more reliable or scalable, enable new types of measurements or integration across data types, or improve interpretability and usability for researchers and clinicians.

A key requirement is that the novelty must be in the informatics method or algorithm itself. The FOA is explicit that proposals are not responsive if they mainly apply existing methods and claim innovation primarily in the biological or clinical question being studied. In other words, the review focus is on whether the project advances the state of the art in cancer informatics (new algorithms, new computational frameworks, new data integration or visualization paradigms, new approaches to learning from complex cancer data, etc.), and whether there is a clear, well-argued rationale for why that technical innovation will benefit the broader cancer research community.

The award information provided in the source indicates an award ceiling of $275,000 (as listed), with an original closing date of 2023-11-17, and a creation date of 2022-12-22. The funding instrument is a grant, categorized under education and health-related activities, and it is associated with CFDA numbers 93.393, 93.394, 93.395, 93.396, and 93.399.

Eligibility is broad and includes many types of U.S. organizations and institutions, such as state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses); small businesses; and other entities. The FOA also explicitly highlights additional eligible applicants, including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving institutions, HBCUs, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations). This wide eligibility reflects an intent to draw strong technical ideas from a diverse set of settings, including institutions working closely with communities affected by cancer disparities.

Overall, this opportunity is best suited for teams that can clearly articulate a technical gap in current cancer informatics, propose an original method or algorithm to fill that gap, and explain how the resulting capability could accelerate or enhance cancer research broadly. The most competitive applications under this FOA are likely to be those that treat the cancer use case as a proving ground for a new informatics advance, rather than treating informatics as a supporting tool for a primarily biological or clinical study.

  • The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Development of Innovative Informatics Methods and Algorithms for Cancer Research and Management (R21 Clinical Trial Optional)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.399.
  • This funding opportunity was created on 2022-12-22.
  • Applicants must submit their applications by 2023-11-17. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $275,000.00 in funding.
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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