Development of Animal Models and Related Materials for HIV/AIDS Research (R24 Clinical Trials Not Allowed) | PAR 22 204

Opportunity Information: Apply for PAR 22 204

The NIH Office of Research Infrastructure Programs (ORIP) is soliciting applications under PAR-22-204 for an R24 resource-focused grant opportunity titled "Development of Animal Models and Related Materials for HIV/AIDS Research (R24 Clinical Trials Not Allowed)." The central purpose of this program is to strengthen HIV/AIDS research capacity by supporting the development, characterization, or improvement of animal models that are especially useful for HIV/AIDS studies, as well as the creation of associated biological materials and enabling tools. In addition to building or refining the models themselves, the opportunity also supports efforts that improve access to information about these specialized models or to data generated from their use, recognizing that well-curated, shareable knowledge can be as valuable to the research community as the animals or reagents.

A key requirement is that the proposed resources must have broad, NIH-wide relevance rather than serving a narrow or single-lab need. ORIP emphasizes that the animal models, biological materials, or technological tools developed through this award must be broadly applicable to the scientific interests of at least two or more NIH Institutes or Centers. This is not a program for highly specialized, limited-use resources. Applications are expected to show that the resource will meaningfully advance HIV/AIDS research across a wider community and enable multiple lines of investigation, not just one disease question or one experimental niche. Proposals that focus on developing only a limited number of resources, or resources unlikely to have broad impact on HIV/AIDS research, are explicitly described as unacceptable for this funding announcement.

Another major theme is that the supported models and tools should address complex biology that spans more than one organ system. To align with ORIP's NIH-wide infrastructure mission and the priorities of the NIH Office of AIDS Research, applicants must propose work that explores multiple body systems or evaluates diseases and processes that affect multiple body systems. This reflects the reality that HIV infection and HIV-associated conditions often involve interconnected effects across immunologic, neurologic, cardiovascular, metabolic, gastrointestinal, and other systems. The program is therefore oriented toward resources that can help researchers study HIV/AIDS in ways that capture this multi-system complexity, rather than resources that are relevant to only a single, isolated biological compartment.

Applications must also make a clear, evidence-based case for need and impact. ORIP expects applicants to describe why the proposed model, material, or information resource is needed now, what gap it fills, and how it will change what HIV/AIDS researchers can do in practice. In other words, the application should not only describe technical development plans but also demonstrate the downstream value to the broader field, including how the resource could enable new experiments, improve reproducibility, accelerate translation, or open up research questions that are currently difficult or impossible to address due to lack of appropriate models or insufficient access to model-related data.

Administratively, this is an NIH discretionary grant program in the health funding activity category (CFDA 93.351) using the R24 mechanism, and it explicitly does not allow clinical trials. That framing matters because the R24 is typically used to support shared resources, infrastructure, and community-enabling projects rather than hypothesis-driven clinical interventions. The listed original closing date is January 7, 2025, and the opportunity was created on September 9, 2022. An award ceiling and expected number of awards are not specified in the provided source data, which generally means applicants should rely on the full FOA and NIH budget guidance for allowable costs and appropriate scale.

Eligibility is broad and includes many types of domestic organizations: state, county, and local governments; special districts; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized tribal governments, as listed); public housing authorities/Indian housing authorities; nonprofits (both 501(c)(3) and non-501(c)(3), other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. ORIP also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. At the same time, there are important restrictions on foreign participation: non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components are allowed as defined by the NIH Grants Policy Statement, meaning a U.S. applicant may include certain foreign elements in the project when justified and compliant with NIH policy.

Taken together, this opportunity is best understood as NIH support for shared, high-value research infrastructure for HIV/AIDS science: animal models and related resources that are designed from the start to be broadly useful, multi-system relevant, and impactful across multiple NIH constituencies. Successful applications are expected to emphasize community benefit, wide applicability, and clear plans for generating and disseminating resources or information that can measurably strengthen the national HIV/AIDS research enterprise.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Development of Animal Models and Related Materials for HIV/AIDS Research (R24 Clinical Trials Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.351.
• This funding opportunity was created on 2022-09-09.
• Applicants must submit their applications by 2025-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 22 204

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