Opportunity Information: Apply for PAR 22 204
The NIH Office of Research Infrastructure Programs (ORIP) is soliciting applications under PAR-22-204 for an R24 resource-focused grant opportunity titled "Development of Animal Models and Related Materials for HIV/AIDS Research (R24 Clinical Trials Not Allowed)." The central purpose of this program is to strengthen HIV/AIDS research capacity by supporting the development, characterization, or improvement of animal models that are especially useful for HIV/AIDS studies, as well as the creation of associated biological materials and enabling tools. In addition to building or refining the models themselves, the opportunity also supports efforts that improve access to information about these specialized models or to data generated from their use, recognizing that well-curated, shareable knowledge can be as valuable to the research community as the animals or reagents.
A key requirement is that the proposed resources must have broad, NIH-wide relevance rather than serving a narrow or single-lab need. ORIP emphasizes that the animal models, biological materials, or technological tools developed through this award must be broadly applicable to the scientific interests of at least two or more NIH Institutes or Centers. This is not a program for highly specialized, limited-use resources. Applications are expected to show that the resource will meaningfully advance HIV/AIDS research across a wider community and enable multiple lines of investigation, not just one disease question or one experimental niche. Proposals that focus on developing only a limited number of resources, or resources unlikely to have broad impact on HIV/AIDS research, are explicitly described as unacceptable for this funding announcement.
Another major theme is that the supported models and tools should address complex biology that spans more than one organ system. To align with ORIP's NIH-wide infrastructure mission and the priorities of the NIH Office of AIDS Research, applicants must propose work that explores multiple body systems or evaluates diseases and processes that affect multiple body systems. This reflects the reality that HIV infection and HIV-associated conditions often involve interconnected effects across immunologic, neurologic, cardiovascular, metabolic, gastrointestinal, and other systems. The program is therefore oriented toward resources that can help researchers study HIV/AIDS in ways that capture this multi-system complexity, rather than resources that are relevant to only a single, isolated biological compartment.
Applications must also make a clear, evidence-based case for need and impact. ORIP expects applicants to describe why the proposed model, material, or information resource is needed now, what gap it fills, and how it will change what HIV/AIDS researchers can do in practice. In other words, the application should not only describe technical development plans but also demonstrate the downstream value to the broader field, including how the resource could enable new experiments, improve reproducibility, accelerate translation, or open up research questions that are currently difficult or impossible to address due to lack of appropriate models or insufficient access to model-related data.
Administratively, this is an NIH discretionary grant program in the health funding activity category (CFDA 93.351) using the R24 mechanism, and it explicitly does not allow clinical trials. That framing matters because the R24 is typically used to support shared resources, infrastructure, and community-enabling projects rather than hypothesis-driven clinical interventions. The listed original closing date is January 7, 2025, and the opportunity was created on September 9, 2022. An award ceiling and expected number of awards are not specified in the provided source data, which generally means applicants should rely on the full FOA and NIH budget guidance for allowable costs and appropriate scale.
Eligibility is broad and includes many types of domestic organizations: state, county, and local governments; special districts; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized tribal governments, as listed); public housing authorities/Indian housing authorities; nonprofits (both 501(c)(3) and non-501(c)(3), other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. ORIP also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. At the same time, there are important restrictions on foreign participation: non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components are allowed as defined by the NIH Grants Policy Statement, meaning a U.S. applicant may include certain foreign elements in the project when justified and compliant with NIH policy.
Taken together, this opportunity is best understood as NIH support for shared, high-value research infrastructure for HIV/AIDS science: animal models and related resources that are designed from the start to be broadly useful, multi-system relevant, and impactful across multiple NIH constituencies. Successful applications are expected to emphasize community benefit, wide applicability, and clear plans for generating and disseminating resources or information that can measurably strengthen the national HIV/AIDS research enterprise.Apply for PAR 22 204
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Development of Animal Models and Related Materials for HIV/AIDS Research (R24 Clinical Trials Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.351.
- This funding opportunity was created on 2022-09-09.
- Applicants must submit their applications by 2025-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is this grant opportunity?
This is an NIH Office of Research Infrastructure Programs (ORIP) funding opportunity under PAR-22-204 for an R24 resource-focused award titled "Development of Animal Models and Related Materials for HIV/AIDS Research (R24 Clinical Trials Not Allowed)." It supports shared research resources for the HIV/AIDS research community.
What is the main purpose of PAR-22-204?
The central purpose is to strengthen HIV/AIDS research capacity by supporting the development, characterization, or improvement of animal models that are especially useful for HIV/AIDS studies, along with related biological materials and enabling tools. The program also supports efforts to improve access to information about these models or data generated from their use.
What types of projects does ORIP want to fund under this R24?
Projects focused on building community-enabling resources, including:
- Developing new animal models for HIV/AIDS research
- Characterizing existing models to increase their usefulness and reliability
- Improving or refining existing models to better reflect HIV biology and HIV-associated conditions
- Creating biological materials and related reagents associated with those models
- Developing enabling tools or technologies tied to the use of these models
- Improving access to model-related information and/or data generated from use of the models (with an emphasis on well-curated, shareable knowledge)
Does the program support efforts focused on information sharing and data access?
Yes. In addition to creating or improving the animal models and materials themselves, the opportunity explicitly supports work that improves access to information about specialized models and/or access to data produced from their use. ORIP notes that well-curated, shareable knowledge can be as valuable to the community as the animals or reagents.
What does ORIP mean by "resource-focused" in this context?
The R24 mechanism here is positioned as support for shared resources, infrastructure, and community-enabling projects, rather than a narrow, single-project effort. The emphasis is on resources that other researchers can use to advance HIV/AIDS science.
Are clinical trials allowed under this funding opportunity?
No. The funding opportunity title explicitly states "Clinical Trials Not Allowed."
How broad does the impact of the proposed resource need to be?
A key requirement is that the animal model(s), materials, or tools supported by this award must have broad, NIH-wide relevance rather than serving a narrow or single-lab need. ORIP emphasizes that the resource must be broadly applicable to the scientific interests of at least two or more NIH Institutes or Centers.
What kinds of proposals are described as unacceptable?
Based on the provided information, ORIP indicates that proposals are unacceptable if they:
- Focus on developing only a limited number of resources
- Propose resources unlikely to have broad impact on HIV/AIDS research
- Primarily serve a narrow purpose (for example, a single-lab or highly specialized, limited-use resource)
Why does ORIP require NIH-wide relevance and multi-Institute/Center applicability?
ORIP’s infrastructure mission is to support shared, high-value resources that strengthen research capacity across NIH. For this opportunity, the expectation is that the resulting models/materials/tools will meaningfully advance HIV/AIDS research for a broader community and support multiple lines of investigation relevant to more than one NIH Institute or Center.
Does the opportunity prioritize models that address more than one organ system?
Yes. A major theme is that supported models and tools should address complex biology that spans more than one organ system. Applicants must propose work that explores multiple body systems or evaluates diseases and processes affecting multiple systems, reflecting the multi-system nature of HIV infection and HIV-associated conditions.
What kinds of multi-system impacts are referenced in the opportunity description?
The description notes that HIV infection and HIV-associated conditions often have interconnected effects across multiple systems, including immunologic, neurologic, cardiovascular, metabolic, gastrointestinal, and other systems. The program is oriented toward resources that help researchers study this multi-system complexity rather than a single isolated compartment.
What does ORIP expect applicants to demonstrate about need and impact?
Applications must make a clear, evidence-based case for:
- Why the proposed model/material/information resource is needed now
- What gap it fills
- How it will change what HIV/AIDS researchers can do in practice
The emphasis is not only on technical plans but also on downstream value to the broader field, such as enabling new experiments, improving reproducibility, accelerating translation, or opening research questions that are currently difficult due to lack of appropriate models or insufficient access to model-related data.
Which NIH office is running this opportunity?
The opportunity is associated with the NIH Office of Research Infrastructure Programs (ORIP).
What funding mechanism is used?
The opportunity uses the NIH R24 mechanism and is described as a discretionary grant program in the health funding activity category.
What is the CFDA number for this program?
The CFDA number listed is 93.351.
When was the opportunity created and what is the closing date mentioned?
The opportunity was created on September 9, 2022. The listed original closing date is January 7, 2025.
Is there an award ceiling or expected number of awards provided?
No. The provided source data does not specify an award ceiling or the expected number of awards. Applicants are expected to rely on the full Funding Opportunity Announcement (FOA) and NIH budget guidance for allowable costs and an appropriate project scale.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S.-based organizations, including:
- State, county, and local governments
- Special districts
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Tribal organizations (including those other than federally recognized tribal governments, as listed)
- Public housing authorities / Indian housing authorities
- Nonprofits (501(c)(3) and non-501(c)(3), other than institutions of higher education)
- For-profit organizations (other than small businesses)
- Small businesses
Are any additional applicant categories specifically highlighted as eligible?
Yes. ORIP also highlights eligibility for categories such as:
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISI)
- Hispanic-serving institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Faith-based or community-based organizations
- Eligible federal agencies
- Regional organizations
- U.S. territories or possessions
Can a non-U.S. (foreign) organization apply directly?
No. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply based on the information provided.
Can a U.S. organization include a non-domestic component?
No. The information provided states that non-domestic components of U.S. organizations are also not eligible to apply.
Are foreign components allowed at all?
Yes. While non-U.S. entities cannot apply directly, foreign components are allowed as defined by the NIH Grants Policy Statement. This means a U.S. applicant may be able to include certain foreign elements in the project when justified and compliant with NIH policy.
What overall theme should a competitive application emphasize?
The opportunity is best understood as NIH support for shared, high-value research infrastructure for HIV/AIDS science. Competitive applications should emphasize:
- Community benefit and broad usability
- Relevance to at least two or more NIH Institutes or Centers
- Multi-system (multi-organ) relevance
- A clear case for need and measurable impact
- Plans for generating and disseminating resources and/or information that strengthens HIV/AIDS research capacity
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 22 204) also looked into and applied for these:
| Funding Opportunity |
|---|
| Resource-Related Research Projects for Development of Animal Models and Related Materials (R24 Clinical Trials Not-Allowed) Apply for RFA OD 22 013 Funding Number: RFA OD 22 013 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed) Apply for PAR 22 225 Funding Number: PAR 22 225 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Centers of Biomedical Research Excellence (COBRE) Phase 1 (P20 - Clinical Trial Optional) Apply for PAR 22 250 Funding Number: PAR 22 250 Agency: National Institutes of Health Category: Health Funding Amount: $1,500,000 |
| Agency for Healthcare Research and Quality (AHRQ)-sponsored National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32) Apply for PA 22 251 Funding Number: PA 22 251 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: Case Dependent |
| Limited Competition: The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL) (U24 Clinical Trial Not Allowed) Apply for RFA HG 22 020 Funding Number: RFA HG 22 020 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Limited Competition: IDeA Regional Entrepreneurship Development (I-RED) Program (STTR) (UT2 Clinical Trial Not Allowed) Apply for PAR 22 254 Funding Number: PAR 22 254 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space Clinical Resource (ACR) (U24 Clinical Trial Not Allowed) Apply for RFA HG 22 021 Funding Number: RFA HG 22 021 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Schizophrenia and related disorders during mid- to late-life (R01 Clinical Trial Optional) Apply for RFA MH 22 270 Funding Number: RFA MH 22 270 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Botulinum Toxin Potency Assay using Tissue Chips (BoT PATCh) (U43/U44 - Clinical Trail Not Allowed) Apply for RFA TR 22 032 Funding Number: RFA TR 22 032 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Clinical Research Sites for the Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT sites) (U24 Clinical Trial Not Allowed) Apply for RFA NS 22 031 Funding Number: RFA NS 22 031 Agency: National Institutes of Health Category: Health Funding Amount: $275,000 |
| Data Coordinating Center for the Network of Excellence in Neuroscience Clinical Trials (NEXT - DCC) (U01 Clinical Trial Not Allowed) Apply for RFA NS 22 030 Funding Number: RFA NS 22 030 Agency: National Institutes of Health Category: Health Funding Amount: $1,300,000 |
| Schizophrenia and related disorders during mid- to late-life (R21 Clinical Trial Optional) Apply for RFA MH 22 271 Funding Number: RFA MH 22 271 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIAID Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional) Apply for PAR 22 241 Funding Number: PAR 22 241 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Botulinum Toxin Potency Assay using Tissue Chips (BoT PATCh) (UT1, UT2 Clinical Trail Not Allowed) Apply for RFA TR 22 031 Funding Number: RFA TR 22 031 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Clinical Coordinating Center for the Network of Excellence in Neuroscience Clinical Trials (NEXT - CCC) (U01 Clinical Trial Not Allowed) Apply for RFA NS 22 029 Funding Number: RFA NS 22 029 Agency: National Institutes of Health Category: Health Funding Amount: $1,750,000 |
| REQUEST FOR INFORMATION (RFI); Lowland Health Apply for 72066322RFI000011 Funding Number: 72066322RFI000011 Agency: Ethiopia USAID-Addis Ababa Category: Health Funding Amount: Case Dependent |
| Consortium for Design of TB Drug Regimens (UM1 Clinical Trial Not Allowed) Apply for RFA AI 22 059 Funding Number: RFA AI 22 059 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Diversity Centers for Genome Research (UG3/UH3 Clinical Trials Optional) Apply for RFA HG 22 027 Funding Number: RFA HG 22 027 Agency: National Institutes of Health Category: Health Funding Amount: $300,000 |
| Diversity Centers for Genome Research (U54 Clinical Trials Optional) Apply for RFA HG 22 026 Funding Number: RFA HG 22 026 Agency: National Institutes of Health Category: Health Funding Amount: $1,400,000 |
| AHRQ Mentored Research Scientist Career Development Award (K01) Apply for PA 22 255 Funding Number: PA 22 255 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: Case Dependent |
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